Additional Information for Microcrystalline Cellulose
Microcrystalline cellulose is a commonly used excipient in the pharmaceutical industry. It is a refined wood pulp that consists of small, crystalline particles of cellulose. It is primarily used as a binder, diluent, and disintegrant in the formulation of tablets and capsules.
As a binder, microcrystalline cellulose helps to hold the active ingredients together and provide the necessary mechanical strength to the tablet or capsule. It also improves the flowability of the powder mixture during the manufacturing process.
As a diluent, microcrystalline cellulose is used to increase the bulk of the tablet or capsule without significantly affecting the drug content. This is particularly useful when the active ingredient is present in a small quantity.
As a disintegrant, microcrystalline cellulose helps the tablet or capsule to break apart and release the active ingredient when it comes into contact with water or gastric fluids in the body. This ensures that the drug is properly absorbed and its therapeutic effect is achieved.
Microcrystalline cellulose is considered safe for use in pharmaceutical formulations and has been approved by regulatory authorities such as the U.S. Food and Drug Administration (FDA). It is widely used in the production of various oral solid dosage forms, including tablets, capsules, and granules.
In summary, microcrystalline cellulose is a versatile excipient that plays a crucial role in the formulation of pharmaceutical products. It provides binding, dilution, and disintegration properties, making it an essential component in the manufacturing of tablets and capsules.